Decrease in serum calcitriol (but not free 25-hydroxyvitamin D) concentration in hip fracture healing

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F21%3AN0000021" target="_blank" >RIV/00023728:_____/21:N0000021 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/21:43921121 RIV/00216208:11110/21:10422948 RIV/00064211:_____/21:W0000031

Result on the web

<a href="https://doi.org/10.1007/s40618-020-01489-x" target="_blank" >https://doi.org/10.1007/s40618-020-01489-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s40618-020-01489-x" target="_blank" >10.1007/s40618-020-01489-x</a>

Result language

angličtina

Original language name

Decrease in serum calcitriol (but not free 25-hydroxyvitamin D) concentration in hip fracture healing

Original language description

Objective To assess the decrease in serum calcitriol concentrations after hip fracture. Methods Serum concentrations of calcitriol, 25(OH)D, parathyroid hormone (PTH), directly measured free 25(OH)D, and indices of bone formation were measured in elderly patients with hip fracture (HF) and patients with elective hip replacement (EHR) at admission and after 7 weeks. Results A total of 45 patients with HF and 17 patients with EHR completed this prospective study. Baseline serum calcitriol levels were <= 60 pmol/l in 26% of the HF patients. After 7 weeks, they significantly decreased (p < 0.001). In patients with EHR, serum calcitriol was within the reference range in all but one patient and did not change during the 7-week recovery phase. Seven weeks after HF, a significant positive relationship was observed between the change in calcitriol and serum 25(OH)D concentration (r = 0.385, p = 0.009) and free 25(OH)D (r = 0.296, p = 0.048), and a decrease in calcitriol during recovery was associated with a decrease in serum PTH (p = 0.038). Seven weeks after HF, changes in both serum PTH and serum 25(OH)D concentrations contributed to the prediction of changes in serum calcitriol (R-2 = 0.190, p = 0.012). Conclusions Unlike patients with EHR, subjects with HF had low serum 25(OH)D and low free 25(OH)D concentrations at admission, while their serum 1,25D levels were relatively elevated. Decreases in circulating calcitriol levels in the 7 weeks following hip surgery were associated with a resolution of secondary hyperparathyroidism and low availability of free 25(OH)D.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of endocrinological investigation

ISSN

0391-4097

e-ISSN

1720-8386

Volume of the periodical

44

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

1847-1855

UT code for WoS article

000611931300002

EID of the result in the Scopus database

2-s2.0-85099944136