A decrease in serum 1,25(OH)(2)D after elective hip replacement and during bone healing is associated with changes in serum iron and plasma FGF23

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F22%3AN0000002" target="_blank" >RIV/00023728:_____/22:N0000002 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/22:10437862 RIV/00216208:11120/22:43922926 RIV/00064211:_____/22:W0000008

Result on the web

<a href="https://doi.org/10.1007/s40618-022-01746-1" target="_blank" >https://doi.org/10.1007/s40618-022-01746-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s40618-022-01746-1" target="_blank" >10.1007/s40618-022-01746-1</a>

Result language

angličtina

Original language name

A decrease in serum 1,25(OH)(2)D after elective hip replacement and during bone healing is associated with changes in serum iron and plasma FGF23

Original language description

Although calcitriol is essential for bone healing, its serum concentrations are low after hip surgery, and they continue to decline during bone healing. This study aimed to test the hypothesis of an association of changes in calcitriol production with the status of fibroblast growth factor 23 (FGF23) and iron deficiency after elective hip replacement for coxarthrosis. Methods In this prospective study, we measured the biomarkers of 17 patients undergoing elective hip replacement on admission, on the first day after surgery, and at the regular check-up after 48 +/- 8 days. The serum concentrations of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, transferrin, ferritin, parathyroid hormone, intact plasma FGF23 (iFGF23) and C-terminal FGF23 (cFGF23) were determined. Results In our patients who underwent elective hip replacement, significant correlations existed between the percent change in the conversion rate of 25(OH)D to 1,25(OH)(2)D, plasma intact to C-terminal FGF23 ratio, and serum iron. Conclusions The production of calcitriol is compromised after elective hip replacement surgery, leading to reduced levels of active vitamin D in the serum. Significant correlations between the percent change in the conversion rate of 25(OH)D to 1,25(OH)(2)D, plasma intact to C-terminal FGF23 ratio, and serum iron on the first day as well as 7 weeks after surgery could inspire future studies to determine whether and how calcitriol deficiency should be corrected, especially in fracture cases.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of endocrinological investigation

ISSN

0391-4097

e-ISSN

1720-8386

Volume of the periodical

45

Issue of the periodical within the volume

5

Country of publishing house

IT - ITALY

Number of pages

6

Pages from-to

1039-1044

UT code for WoS article

000746761200001

EID of the result in the Scopus database

2-s2.0-85123494142