Chemokine and Cytokine Profiles in Patients with Hand Osteoarthritis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F21%3AN0000033" target="_blank" >RIV/00023728:_____/21:N0000033 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10419621
Result on the web
<a href="https://doi.org/10.3390/biom11010004" target="_blank" >https://doi.org/10.3390/biom11010004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biom11010004" target="_blank" >10.3390/biom11010004</a>
Alternative languages
Result language
angličtina
Original language name
Chemokine and Cytokine Profiles in Patients with Hand Osteoarthritis
Original language description
The development of hand osteoarthritis (HOA) and its progression into the erosive subset are unclear, but inflammation is suspected to be the main source. To verify the involvement of inflammation in HOA pathogenesis, we evaluate serum inflammatory mediators and their association with HOA-related clinical features in patients. 153 participants (50 non-erosive HOA patients, 54 erosive HOA patients, and 49 healthy control subjects) were included in this study. All patients underwent clinical examination, which included assessment of tender and swollen small hand joints, ultrasound (US) examination, and self-reported measures (e.g., AUSCAN or algofunctional indexes). Serum inflammatory mediators were quantified using human cytokine 27-plex immunoassay. We employed linear modelling, correlation analysis, and resampling statistics to evaluate the association of these mediators to HOA. We identified increased levels of nine inflammatory mediators (e.g., eotaxin, monocyte chemoattractant protein 1, interleukin-8, and tumour necrosis factor) in HOA patients compared to healthy controls. Increased mediators correlated with ultrasound findings as well as with clinically tender and swollen joint counts in patients with erosive HOA. However, none of the mediators distinguished between erosive and non-erosive HOA subtypes. Our findings support the hypothesis on the involvement of inflammation in HOA.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30226 - Rheumatology
Result continuities
Project
<a href="/en/project/NV18-01-00542" target="_blank" >NV18-01-00542: Prognostic factors of erosive hand osteoarthritis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomolecules
ISSN
2218-273X
e-ISSN
2218-273X
Volume of the periodical
11
Issue of the periodical within the volume
Art. Nr.4
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
1-12
UT code for WoS article
000609855000001
EID of the result in the Scopus database
2-s2.0-85098787654