Lower serum clusterin levels in patients with erosive hand osteoarthritis are associated with more pain

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10377542" target="_blank" >RIV/00216208:11110/18:10377542 - isvavai.cz</a>

Alternative codes found

RIV/00023728:_____/18:N0000048

Result on the web

<a href="https://doi.org/10.1186/s12891-018-2179-3" target="_blank" >https://doi.org/10.1186/s12891-018-2179-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12891-018-2179-3" target="_blank" >10.1186/s12891-018-2179-3</a>

Result language

angličtina

Original language name

Lower serum clusterin levels in patients with erosive hand osteoarthritis are associated with more pain

Original language description

Background: The aims of this study were to analyse the serum concentrations of clusterin (CLU) in patients with hand osteoarthritis (OA) and in healthy controls, to compare CLU levels between patients with erosive and non-erosive disease, and to examine the association of CLU levels with clinical and laboratory parameters. Methods: A total of 135 patients with hand OA (81 with erosive and 54 with non-erosive disease) and 53 healthy individuals were included in this study. All patients underwent clinical and hand joint ultrasound examination. The Australian/Canadian (AUSCAN) hand osteoarthritis index, algofunctional index and a visual analogue scale (VAS) for the measurement of pain were assessed. Serum levels of CLU were measured by an enzyme-linked immunosorbent assay (ELISA). Results: Serum levels of CLU were significantly lower in patients with hand OA than in control subjects (p &lt; 0.0001). In addition, patients with erosive hand OA had significantly lower CLU levels than those with non-erosive disease (p = 0.044). Negative correlations between CLU levels and pain as assessed by the AUSCAN score and the VAS were found in patients with erosive hand OA (r = -0.275; p = 0.013 and r= -0.220; p = 0.049, respectively). Conclusion: The present study demonstrates that lower concentrations of CLU are found in hand OA patients than in healthy individuals, especially in those with erosive disease, and that CLU concentrations have a negative association with hand pain.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30226 - Rheumatology

Project

<a href="/en/project/NV18-01-00542" target="_blank" >NV18-01-00542: Prognostic factors of erosive hand osteoarthritis</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Musculoskeletal Disorders

ISSN

1471-2474

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

July

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

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UT code for WoS article

000440225600007

EID of the result in the Scopus database

2-s2.0-85050723088