Circulating miRNAs in hand osteoarthritis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F23%3AN0000016" target="_blank" >RIV/00023728:_____/23:N0000016 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/23:10464259
Result on the web
<a href="https://doi.org/10.1016/j.joca.2022.10.021" target="_blank" >https://doi.org/10.1016/j.joca.2022.10.021</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.joca.2022.10.021" target="_blank" >10.1016/j.joca.2022.10.021</a>
Alternative languages
Result language
angličtina
Original language name
Circulating miRNAs in hand osteoarthritis
Original language description
Objective: Hand osteoarthritis (OA) is a frequent musculoskeletal disorder with an increasing prevalence during ageing. This study aimed to evaluate circulating microRNAs (miRNAs) in the plasma of patients with hand OA compared with age-and sex-matched healthy control subjects.Methods: In total, 238 participants (96 with erosive and 73 with non-erosive hand OA patients and 69 healthy control subjects) were included in this study. All patients underwent clinical examinations, including self-reported measures (AUSCAN and Algofunctional index). Radiographs of both hands were scored with the Kallman scale. The profile of miRNAs in plasma was screened using TaqManTM Low-Density Array, and candidate miRNAs were validated on two quantitative real-time PCR (qRT-PCR) systems (QuantStudio and SmartChip).Results: Of all the 754 miRNAs, 40 miRNAs were different between hand OA patients and healthy control subjects in the screening cohort. Following the two-phase validation process, three miRNAs (miR-23a-3p, miR-146a-5p, and miR-652-3p) were increased in patients with hand OA compared with healthy control subjects and were associated with the AUSCAN sum score and AUSCAN pain. Furthermore, an inverse correlation of miR-222-3p with the Kallman radiographic score was found. The expression of miRNAs did not differ between erosive and non-erosive hand OA.Conclusion: The profile of circulating miRNAs could unveil candidate biomarkers associated with hand OA symptoms. Longitudinal studies are required to determine the role of miRNAs in hand OA.(c) 2022 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30226 - Rheumatology
Result continuities
Project
<a href="/en/project/NV18-01-00542" target="_blank" >NV18-01-00542: Prognostic factors of erosive hand osteoarthritis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Osteoarthritis Cartilage.
ISSN
1063-4584
e-ISSN
1522-9653
Volume of the periodical
31
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
228-237
UT code for WoS article
000936554400001
EID of the result in the Scopus database
2-s2.0-85143289685