The pre-clinical phase of rheumatoid arthritis: From risk factors to prevention of arthritis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F21%3AN0000077" target="_blank" >RIV/00023728:_____/21:N0000077 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/21:10430278

Result on the web

<a href="https://doi.org/10.1016/j.autrev.2021.102797" target="_blank" >https://doi.org/10.1016/j.autrev.2021.102797</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.autrev.2021.102797" target="_blank" >10.1016/j.autrev.2021.102797</a>

Result language

angličtina

Original language name

The pre-clinical phase of rheumatoid arthritis: From risk factors to prevention of arthritis

Original language description

Rheumatoid arthritis (RA) is a chronic autoimmune disease considered as a multistep process spanning from the interaction of genetic (e.g., shared epitope or non-HLA loci), environmental and behavioral risk factors (e.g., smoking) leading to breaking immune tolerance and autoimmune processes such as the production of autoantibodies (e.g., antibodies against citrullinated proteins ACPA or rheumatoid factors, RF), development of the first symptoms without clinical arthritis, and, finally, the manifestation of arthritis. Despite the typical joint involvement in established RA, the pathogenesis of the disease likely begins far from joint structures: in the lungs or periodontium in association with citrullination, intestinal microbiome, or adipose tissue, which supports normal findings in synovial tissue in ACPA+ patients with arthralgia. The presence of ACPA is detectable even years before the first manifestation of RA. The pre-clinical phase of RA is the period preceding clinically apparent RA with ACPA contributing to the symptoms without subclinical inflammation. While the combination of ACPA and RF increases the risk of progression to RA by up to 10 times, increasing numbers of novel autoantibodies are to be investigated to contribute to the increased risk and pathogenesis of RA. With growing knowledge about the course of RA, new aspiration emerges to cure and even prevent RA, shifting the ?window of opportunity? to the pre-clinical phases of RA. The clinical definition of individuals at risk of developing RA (clinically suspect arthralgia, CSA) makes it possible to unify these at-risk individuals? clinical characteristics for ?preventive? treatment in ongoing clinical trials using mostly biological or conventional synthetic disease-modifying drugs. However, the combination of symptoms, laboratory, and imaging biomarkers may be the best approach to select the correct target at-risk population. The current review aims to explore different phases of RA and discuss the potential of (non)pharmacological intervention aiming to prevent RA.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30226 - Rheumatology

Project

<a href="/en/project/NV17-32612A" target="_blank" >NV17-32612A: Clinically suspect arhralgia: characteristics of the preclinical phase of rheumatoid arthritis</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Autoimmunity reviews

ISSN

1568-9972

e-ISSN

1873-0183

Volume of the periodical

20

Issue of the periodical within the volume

Art Nr. 102797

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

17

Pages from-to

1-17

UT code for WoS article

000717464000001

EID of the result in the Scopus database

2-s2.0-85104144442