Integrative non-pharmacological care for individuals at risk of rheumatoid arthritis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F24%3AN0000052" target="_blank" >RIV/00023728:_____/24:N0000052 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/24:10474137 RIV/00216208:11510/24:10474137

Result on the web

<a href="https://doi.org/10.1007/s00296-023-05507-y" target="_blank" >https://doi.org/10.1007/s00296-023-05507-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00296-023-05507-y" target="_blank" >10.1007/s00296-023-05507-y</a>

Result language

angličtina

Original language name

Integrative non-pharmacological care for individuals at risk of rheumatoid arthritis

Original language description

There is increasing knowledge in the recognition of individuals at risk for progression to rheumatoid arthritis (RA) before the clinical manifestation of the disease. This prodromal phase preceding the manifestation of RA may represent a "window of opportunity" for preventive interventions that may transform the clinical approach to this disease. However, limited evidence exists in support of effective interventions to delay the onset or even halt the manifestation of RA. Given the multifactorial nature of RA development and disease progression, the latest guidelines for established RA stress the use of integrative interventions and multidisciplinary care strategies, combining pharmacologic treatment with non-pharmacological approaches. Accordingly, individuals at risk of RA could be offered an integrative, multifactorial intervention approach. Current data point toward pharmacological intervention reverting the subclinical inflammation and delay in the disease onset. In addition, targeting life style modifiable factors (smoking cessation, dental health, physical activity, and diet) may presumably improve RA prognosis in individuals at risk, mainly by changes in epigenetics, autoantibodies, cytokines profiles, and microbiome. Nonetheless, the benefits of multidisciplinary interventions to halt the manifestation of RA in at-risk individuals remain unknown. As there is a growing knowledge of possible pharmacological intervention in the preclinical phase, this narrative review aims to provide a comprehensive overview of non-pharmacological treatments in individuals at risk of RA. Considering the mechanisms preceding the clinical manifestation of RA we explored all aspects that would be worth modifying and that would represent an integrative non-pharmacological care for individuals at risk of RA.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30226 - Rheumatology

Project

<a href="/en/project/NU22-05-00226" target="_blank" >NU22-05-00226: The prediction of development of rheumatoid arthritis</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Rheumatology International

ISSN

0172-8172

e-ISSN

1437-160X

Volume of the periodical

44

Issue of the periodical within the volume

3

Country of publishing house

DE - GERMANY

Number of pages

11

Pages from-to

413-423

UT code for WoS article

001136876000002

EID of the result in the Scopus database

2-s2.0-85181505806