Low dose NSAIDs and sysadoas in the management of knee osteoarthritis.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F25%3AN0000048" target="_blank" >RIV/00023728:_____/25:N0000048 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10505789
Result on the web
<a href="https://doi.org/10.1007/s40520-025-03221-2" target="_blank" >https://doi.org/10.1007/s40520-025-03221-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s40520-025-03221-2" target="_blank" >10.1007/s40520-025-03221-2</a>
Alternative languages
Result language
angličtina
Original language name
Low dose NSAIDs and sysadoas in the management of knee osteoarthritis.
Original language description
Osteoarthritis (OA) is a chronic, progressive joint disease characterized by the degradation of articular cartilage, subchondral bone remodeling, synovial inflammation, and osteophyte formation. Despite being a leading cause of disability in older people, effective long-term management of OA remains a significant challenge. Current treatment strategies primarily focus on symptom control, with both non-pharmacological and pharmacological interventions. A systematic literature review followed by a structured Delphi survey was conducted, involving an international Technical Expert Panel (TEP) of OA specialists. The panel evaluated the efficacy, safety, and clinical utility of combining low dose diclofenac and chondroitin sulfate in OA management. The analysis of expert consensus indicated that the combination of low dose diclofenac and chondroitin sulfate may be effective in reducing pain and improving joint function in patients with knee OA. Additionally, this combination could reduce the need for higher doses of NSAIDs, thereby minimizing systemic adverse effects. The combination of low dose diclofenac and chondroitin sulfate represents a promising therapeutic strategy for managing knee OA. Further studies are needed to confirm these findings and optimize therapeutic strategies to improve patient outcomes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30226 - Rheumatology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
AGING CLINICAL AND EXPERIMENTAL RESEARCH
ISSN
1594-0667
e-ISSN
1720-8319
Volume of the periodical
37
Issue of the periodical within the volume
Art. Nr. 317
Country of publishing house
IT - ITALY
Number of pages
10
Pages from-to
1-10
UT code for WoS article
001609745300001
EID of the result in the Scopus database
2-s2.0-105020993107