Nabumetone Induces Less Gastrointestinal Mucosal Changes Than Diclofenac Retard

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F99%3A00000018" target="_blank" >RIV/00023728:_____/99:00000018 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Nabumetone Induces Less Gastrointestinal Mucosal Changes Than Diclofenac Retard

Original language description

The aim of the study was to compare the efficacy and the effects on the mucosa of the gastrointestinal tract (GIT) of nabumetone and diclofenac retard in patients with osteoarthritis (OA). An oper multicentre, randomised, comparative ¨, nedoscopy-blind parallel group study included 201 patients with nabumetone and 193 patients with diclofenac retard suffering from moderate to severe OA of the knee or hip joint. Twelve clinical efficacy variables were assesses and a portion of the population underwent gastroduodenoscopy. All patients exhibited significant improvement in pain severity and pain relief ( p < 0.0001, respectively) but there were no differences between the groups for all the efficacy variables. Eleven per cent of patients on nabumetone and19% on diclofenac experienced GIT side-effects. Sixty-nine patients with nabumetone and 61 with diclofenac underwent gastroduoendoscopy. The differences in the mucosal grade for the oesophagus, stomach and duodenum at baseline were not sig

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

<a href="/en/project/IZ2911" target="_blank" >IZ2911: Microscopic vascular changes,markers of vaskular injury and immunological abnormalities in bronchoalveolar lavage of patients with progressive systemic sclerosi</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

1999

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Rheumatology

ISSN

0770-3198

e-ISSN

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Volume of the periodical

18

Issue of the periodical within the volume

4

Country of publishing house

BE - BELGIUM

Number of pages

6

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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