Polyreactivity and immunoglobulin variable region gene usage in human CD5+ B cells.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F99%3A00000021" target="_blank" >RIV/00023728:_____/99:00000021 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Polyreactivity and immunoglobulin variable region gene usage in human CD5+ B cells.

Original language description

B-lymphocytes that express the pan T cell glycoprotein CD5 (CD5+ or B1 cells) show a variety of features that distinguish them from the bulk of conventional CD5- B cells (B2 cells). Among these are a distinctive surface phenotype and a propensity to produce antibodies that react with low avidity to multiple antigens including self-antigens (i.e.) polyreactive or natural antibodies) which could lead to pathogenic autoantibodies found in autoimmune diseases. Studies on foetal, cord blood and leukaemiaB cells, which express the CD5+ marker implied that: a) number of immunoglobulin variable region (IgV) genes are preferentially expressed in CD5+ B cells; and b) that the production of polyreactive antibodies may be an exclusive feature of CD5+ cells. Studies presented here show that whilst IgV genes in germline, or near germline, configuration that often encode natural antibodies are expressed at high frequency, in CD5+ B cells, the expression of these genes is not restricted to CD5+ B cell

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

<a href="/en/project/IZ3638" target="_blank" >IZ3638: Methotrexate and cyclosporine A in the management of polymyositis and dermatomyositis and new possibilities of asseesing disease activity</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

1999

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Trans-Caucasian Journal of Immunology

ISSN

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e-ISSN

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Volume of the periodical

1

Issue of the periodical within the volume

1

Country of publishing house

GE - GEORGIA

Number of pages

18

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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