The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F20%3AA21026IV" target="_blank" >RIV/61988987:17310/20:A21026IV - isvavai.cz</a>
Result on the web
<a href="https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.13903" target="_blank" >https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.13903</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/1873-3468.13903" target="_blank" >10.1002/1873-3468.13903</a>
Alternative languages
Result language
angličtina
Original language name
The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice
Original language description
Humoral immunity in mammals relies on the function of two developmentally and functionally distinct B-cell subsets-B1 and B2 cells. While B2 cells are responsible for the adaptive response to environmental antigens, B1 cells regulate the production of polyreactive and low-affinity antibodies for innate humoral immunity. The molecular mechanism of B-cell specification into different subsets is understudied. In this study, we identified lysine methyltransferase NSD2 (MMSET/WHSC1) as a critical regulator of B1 cell development. In contrast to its minor impact on B2 cells, deletion of the catalytic domain of NSD2 in primary B cells impairs the generation of B1 lineage. Thus, NSD2, a histone H3 K36 dimethylase, is the first-in-class epigenetic regulator of a B-cell lineage in mice.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
FEBS LETTERS
ISSN
0014-5793
e-ISSN
1873-3468
Volume of the periodical
594
Issue of the periodical within the volume
20
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
3324-3337
UT code for WoS article
000564214800001
EID of the result in the Scopus database
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