Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00424353" target="_blank" >RIV/61388971:_____/13:00424353 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1038/cdd.2013.60" target="_blank" >http://dx.doi.org/10.1038/cdd.2013.60</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/cdd.2013.60" target="_blank" >10.1038/cdd.2013.60</a>

Result language

angličtina

Original language name

Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines

Original language description

Immunogenic cell death induced by cytotoxic compounds contributes to the success of selected chemotherapies by eliciting a protective anticancer immune response, which is mediated by CD4(+) and CD8(+) T cells producing interferon-gamma. In many instances, cancer progression is associated with high titers of tumor-specific antibodies, which become detectable in the serum, but whose functional relevance is elusive. Here, we explored the role of humoral immune responses in the anticancer efficacy of anthracyclines. Chemotherapy reduced the number of tumor-infiltrating B cells, and failed to promote humoral responses against immunodominant tumor antigens. Although anthracycline-based anticancer chemotherapies failed in T cell-deficient mice, they successfully reduced the growth of cancers developing in mice lacking B lymphocytes (due to the injection of a B-cell-depleting anti-CD20 antibody), immunoglobulins (Igs) or Ig receptors (Fc receptor) due to genetic manipulations. These results su

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GA13-14608S" target="_blank" >GA13-14608S: Detailed analysis of specificity, heterogeneity and role of anti-calreticulin antibodies in oncological and autoimmune diseases.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cell Death and Differentiation

ISSN

1350-9047

e-ISSN

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Volume of the periodical

21

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

50-58

UT code for WoS article

000328622100007

EID of the result in the Scopus database

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