Experimental therapy of HPV16 induced tumors with IL12 expressed by recombinant vaccinia virus in mice.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F03%3A00000008" target="_blank" >RIV/00023736:_____/03:00000008 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Experimental therapy of HPV16 induced tumors with IL12 expressed by recombinant vaccinia virus in mice.

Original language description

Recombinant vaccinia viruses were used for intratumoral delivery and expression of IL12 genes in tumors induced by HPV16 in mice. Intratumoral therapy with a low dose of recombinant virus slowed down the growth of TC1 tumors, but never caused their regression. When local virus treatment was combined with antigen-specific, DNA-vaccination therapy, no synergy between the two treatments was observed. The highest efficacy of intratumoral therapy was observed with TC-1/A9 cell subline, with downregulated MHCclass I expression.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NC7552" target="_blank" >NC7552: Imunization against Tumors Characterized by Different Escape Mechanisms</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Medicine

ISSN

1107-3756

e-ISSN

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Volume of the periodical

12

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

789-796

UT code for WoS article

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EID of the result in the Scopus database

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