The presence of clonal granulocyte and CD14+ subpopulations in peripheral blood and bone marrow of patients with refractory cytopenia with multilineage dysplasia but not in patients with "pure" refractory anemia may reflect a multistep pathogenesis of my

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F03%3A00000084" target="_blank" >RIV/00023736:_____/03:00000084 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The presence of clonal granulocyte and CD14+ subpopulations in peripheral blood and bone marrow of patients with refractory cytopenia with multilineage dysplasia but not in patients with "pure" refractory anemia may reflect a multistep pathogenesis of my

Original language description

Clonality assay based on investigation of X-chromosome inactivation patterns of HUMARA gene was performed in 29 female patients with primary MDS. Peripheral blood clonal granulocytes were present in 11 out of 12 patients with RCMD in contrast to only 1 out of 7 females with RA according to the WHO classification. Similar results were found in CD 14+ subpopulation in peripheral blood and in both subpopulations in bone marrow. Patients with clonal subpopulations had significantly poorer prognosis than those with non-clonal subpopulations.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NK7713" target="_blank" >NK7713: The role of detection of clonality in diagnosis, prognosis and treatment of myelodysplatic syndrome</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Blood

ISSN

0006-4971

e-ISSN

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Volume of the periodical

102

Issue of the periodical within the volume

11, S1

Country of publishing house

US - UNITED STATES

Number of pages

1

Pages from-to

"915a"-915a"

UT code for WoS article

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EID of the result in the Scopus database

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