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Array-based analysis of gene expression in childhood lymphoblastic leukemia.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F04%3AI0000010" target="_blank" >RIV/00023736:_____/04:I0000010 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Array-based analysis of gene expression in childhood lymphoblastic leukemia.

  • Original language description

    Gene expression profiles of ten children with acute lymphoblastic leukemia (ALL) were detected using cDNA arrays. For detection of expression profiles we used Atlas Human Cancer cDNA Arrays (Clontech) with 588 genes. Although the study revealed variability of gene expression in many genes, we identified a number of genes with the same expression changes (up-regulation: PCNA, ERCC1; down-regulation: jun-B, BCL-2 related protein A1, CRAF-1, PBP) in most examined patients. Our objective was to identify genes that were differentially expressed in ALL and might contribute to development (and characterisation) of the disease.

  • Czech name

    Analýza využití biočipů k sledování genové exprese u dětské ALL.

  • Czech description

    Expresní profily byly detekovány u 10 dětí s akutní lymfoblastickou leukemií (ALL) pomocí cDNA čipů. Pro detekci byly použity Atlas Human Cancer cDNA Arrays (Clontech) s 588 geny. Ačkoliv studie odhalila expresní variabilitu u mnoha genu, několik genů vykazovalo stejné signifikatní změny exprese (zvýšená exprese: PCNA, ERCC1; snížená exprese: jun-B, BCL-2 related protein A1, CRAF-1, PBP) u většiny testovaných pacientů. Cílem studie bylo identifikovat odlišně exprimované geny u ALL, které by mohly přispívat k rozvoji (a charakterizaci) daného onemocnění.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NM5901" target="_blank" >NM5901: Diferental gene expression analysis in oncohematological diseases.</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Leukemia Research

  • ISSN

    0145-2126

  • e-ISSN

  • Volume of the periodical

    28

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    8

  • Pages from-to

    1-7

  • UT code for WoS article

  • EID of the result in the Scopus database