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Proteome analysis of chronic myelogenous leukemia cells K562 subjected to butyrate treatment.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F04%3AI0000075" target="_blank" >RIV/00023736:_____/04:I0000075 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Proteome analysis of chronic myelogenous leukemia cells K562 subjected to butyrate treatment.

  • Original language description

    Using biochemical and proteome analysis methods we investigated the effects of sodium butyrate (SB) on the proliferation and maturation of CML-derived cell line K562. SB stops cell proliferation and induces erythroid differentiation of K562 cells. Proteome analysis revealed changes in cyclophilin A, SOD1, HSP90 and p23 expression that reflected stress response of cells to SB induction.

  • Czech name

    Proteomová analýza CML buněčných linií K562, vystavených účinku butyrátové terapie.

  • Czech description

    Metodami biochemickými a metodami proteomové analýzy jsme zkoumali účinek inhibitoru histiondeacetyláz, butyrátu sodného (SB), na proliferaci a zrání buněčné linie K562 odvozené od CML. SB zastavuje buněčnou proliferaci a indukuje erytroidní diferenciacibuněk K562. Proteomovou analýzou byly odhaleny změny v expresi cyklofilinu A, SOD1, HSP90 a p23, jež odrážejí stresovou odpověď buněk na indukci SB.

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Affolter, M., Gadola, S., Haeberli, A. a kol. (ed.). Proceedings of the Swiss proteomic society : 2004 congress proteomics for health

  • ISBN

  • ISSN

  • e-ISSN

  • Number of pages

    2

  • Pages from-to

    204-205

  • Publisher name

    SPS

  • Place of publication

    Bern

  • Event location

    Bern

  • Event date

    Dec 6, 2004

  • Type of event by nationality

    EUR - Evropská akce

  • UT code for WoS article