The proteomic study of sodium butyrate antiproliferative/cytodifferentiation effects on K562 cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F06%3A00053397" target="_blank" >RIV/61388971:_____/06:00053397 - isvavai.cz</a>
Alternative codes found
RIV/00023736:_____/06:00006619
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The proteomic study of sodium butyrate antiproliferative/cytodifferentiation effects on K562 cells
Original language description
Employing methods of cell biology and proteome analysis tools, we examined effects of an inhibitor of histone deacetylases, sodium butyrate (SB), on the proliferation/differentiation characteristics of chronic myelogenous leukemia (CML)-derived cells K562. SB suppressed proliferation of K562 cells by inducing cell cycle arrest in G1 phase, which was followed by their transition to G0 phase (decrease of Ki-67 antigen-positive cells) and erythroid differentiation (increased glycophorin A expression and synthesis of hemoglobins). Neither terminal apoptosis (low counts of TUNEL-positive cells) nor necrosis (moderate counts of propidium iodide-positive cells) occurred
Czech name
Proteomová analýza vlivu butyrátu sodného na proliferaci a diferenciaci buněk K562
Czech description
Metodami buněčné biologie a proteomové analýzy byl studován vliv inhibitoru histon deacetyláz, butyrátu sodného, na proliferaci/diferenciaci buněk K562 odvozených od chronické myeloidní leukémie. Bylo zjištěno, že butyrát sodný potlačuje proliferaci buněk K562, avšak nevyvolává apoptózu ani nekrózu. Pomocí proteomové analýzy byly nalezeny proteiny, jejichž exprese byly významně změněna vlivem přídavku butyrátu sodného
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NL7681" target="_blank" >NL7681: Exprimental pharmacotherapy of chronic myelogenous leukemia the proteomic approach</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Blood Cells Molecules and Diseases
ISSN
1079-9796
e-ISSN
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Volume of the periodical
37
Issue of the periodical within the volume
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Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
210-217
UT code for WoS article
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EID of the result in the Scopus database
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