Folic acid does not improve surrogate markers of early atherosclerosis in atorvastatin-treated patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F07%3A00007433" target="_blank" >RIV/00023736:_____/07:00007433 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Folic acid does not improve surrogate markers of early atherosclerosis in atorvastatin-treated patients
Original language description
We examined the expression of l-selectin (CD62L); ?-subunits of integrins LFA-1 (CD11a), Mac-1 (CD11b), and VLA-4 (CD49d); and ß-subunit of ß-2 integrins (CD18) by an immunofluorescence method using single-step staining of whole blood with monoclonal antibodies. The fluorescence was quantified by flow cytometry. Reactivity of the forearm skin microvascular bed to thermal and ischemic stimuli was measured using laser Doppler flowmetry. Postocclusive and thermal reactive hyperemia tests were performed. Statistical analysis used 2-sample t test and paired t test. Homocysteine levels decreased significantly in the folic acid?treated group (11.78 2.7 vs 9.75 1.89 ?mol/L, P < .0001) but did not change in the control group (11.17 2.09 vs 11.88 2.88 ?mol/L). There was no effect of folic acid treatment on leukocyte expression of cell adhesion molecules or microvascular reactivity. The lack of effect of folic acid on microvascular reactivity and leukocyte adhesion molecules supports the
Czech name
Kyselina listová nezlepšuje markery časné aterosklerózy u pacientů na
Czech description
Cílem studie bylo prozkoumat vliv kyseliny listové na terapii statiny u

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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