The translocation of AgNORs in large nucleoli of early granulocyte progenitors in patients suffering from chronic phase of chronic myeloid leukaemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F09%3A00008293" target="_blank" >RIV/00023736:_____/09:00008293 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The translocation of AgNORs in large nucleoli of early granulocyte progenitors in patients suffering from chronic phase of chronic myeloid leukaemia
Original language description
The cytochemistry of AgNORs (silver stained nucleolus organizer region proteins such as nucleophosmin, nucleolin, RNA polymerase and UBF) indicated a distinct translocation of these structures to the nucleolar periphery of early granulocytic progenitors.Such phenomenon appears to be one of markers of aging of these cells without the successive differentiation and is related to the loss of the nucleolar biosynthetic activity and cell proliferation. The translocation of AgNORs in granulocytic progenitorswas more expressed in patients treated with imatinib than in patients after interferon therapy. In this connection, it should be mentioned that the incidence of granulocytic cells in patients treated with imatininib was also significantly smaller
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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