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Generation of reactive oxygen species during apoptosis induced by DNA-damaging agents and/or histone deacetylase inhibitors

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F11%3A00009314" target="_blank" >RIV/00023736:_____/11:00009314 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.hindawi.com/journals/oximed/2011/253529/" target="_blank" >http://www.hindawi.com/journals/oximed/2011/253529/</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1155/2011/253529" target="_blank" >10.1155/2011/253529</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Generation of reactive oxygen species during apoptosis induced by DNA-damaging agents and/or histone deacetylase inhibitors

  • Original language description

    We analyzed the role of ROS in apoptosis induced by DNA-damaging agents (actinomycin D or decitabine) in leukemia cell line CML-T1 and normal peripheral blood lymphocytes (PBL). The possibility of synergism with histone deacetylase inhibitors butyrate orSAHA is also reported. Combined treatment with histone deacetylase inhibitor did not potentiate actinomycin D action, whereas combination of decitabine and SAHA brought synergistic ROS generation and apoptotic features in CML cell line. Appropriate decrease of cell viability indicated promising therapeutic potential of this combination in CML, but side effects on normal PBL should be taken into attention

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    GF - Diseases, pests, weeds and plant protection

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NS9637" target="_blank" >NS9637: Interactions between nuclear and nucleolar proteins controlling cell proliferation and apoptosis effectors during leukemogenesis and therapy of leukemias.</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Oxidative Medicine and Cellular Longevity [online]

  • ISSN

    1942-0900

  • e-ISSN

  • Volume of the periodical

    2011

  • Issue of the periodical within the volume

    253529

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    1-7

  • UT code for WoS article

    000296867800001

  • EID of the result in the Scopus database