Decitabine-induced apoptosis is derived by Puma and Noxa induction in chronic myeloid leukemia cell line as well as in PBL and is potentiated by SAHA

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F11%3A00008919" target="_blank" >RIV/00023736:_____/11:00008919 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s11010-010-0683-3" target="_blank" >http://dx.doi.org/10.1007/s11010-010-0683-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11010-010-0683-3" target="_blank" >10.1007/s11010-010-0683-3</a>

Result language
angličtina
Original language name
Decitabine-induced apoptosis is derived by Puma and Noxa induction in chronic myeloid leukemia cell line as well as in PBL and is potentiated by SAHA
Original language description
Decitabine-induced activation of tumor supressor p53-apoptotic pathway was investigated in leukemic cell line and in normal peripheral blood lymphocytes (PBL). Expression of p53-inducible BH3-only apoptotic proteins Puma and Noxa was elevated and large activation of executive caspases was observed. Combination of SAHA with decitabine brought synergistic effect on apoptosis triggering in CML-T1 cell line, but apoptosis as well as necrosis occured also in PBL. Therefore, promising potential of such combined therapy calls for more detailed investigation of unwanted effects in normal cells.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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