Nutritional hepatic iron overload is not prevented by parenteral hepcidin

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F12%3A00009832" target="_blank" >RIV/00023736:_____/12:00009832 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1017/S0007114512000116" target="_blank" >http://dx.doi.org/10.1017/S0007114512000116</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1017/S0007114512000116" target="_blank" >10.1017/S0007114512000116</a>

Result language
angličtina
Original language name
Nutritional hepatic iron overload is not prevented by parenteral hepcidin
Original language description
The peptide hormone hepcidin functions as a negative regulator of intestinal Fe absorption and Fe recycling. Since its discovery as a systemic negative regulator of Fe metabolism, hepcidin has attracted enormous interest as a potential drug for the treatment and/or prevention of several forms of Fe overload. We therefore tested whether multiple doses of intraperitoneally administered synthetic renatured hepcidin can prevent hepatic Fe loading in mice concurrently fed an Fe-rich diet, and whether the same treatment affects hepatic Fe stores in mice fed a normal diet. Cohorts of male mice were fed either a normal defined diet (180parts per million Fe) or an Fe-rich diet (the same diet supplemented with 2% carbonyl iron for 2 weeks). Concurrently, half ofthe animals in each diet group received 100 ?g of renatured hepcidin intraperitoneally every 12h, for the same 2-week period. The second half of the animals received PBS only. The renatured synthetic hepcidin demonstrated biological acti
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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