Important genes in the pathogenesis of 5q- syndrome and their connection with ribosomal stress and innate immune system pathway

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F12%3A00010460" target="_blank" >RIV/00023736:_____/12:00010460 - isvavai.cz</a>
Result on the web
<a href="http://www.hindawi.com/journals/lrt/2012/179402/" target="_blank" >http://www.hindawi.com/journals/lrt/2012/179402/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2012/179402" target="_blank" >10.1155/2012/179402</a>

Result language
angličtina
Original language name
Important genes in the pathogenesis of 5q- syndrome and their connection with ribosomal stress and innate immune system pathway
Original language description
Myelodysplastic syndrome (MDS) with interstitial deletion of a segment of the long arm of chromosome 5q [del(5q)] is characterized by bone marrow erythroid hyperplasia, atypical megakaryocytes, thrombocythemia, refractory anemia, and low risk of progression to acute myeloid leukemia (AML) compared with other types of MDS. The long arm of chromosome 5 contains two distinct commonly deleted regions (CDRs). The more distal CDR lies in 5q33.1 and contains 40 protein coding genes and genes coding microRNAs (miR-143, miR-145). In 5q- syndrome one allele is deleted that accounts for haploinsufficiency of these genes
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/LC06044" target="_blank" >LC06044: Center for Experimental Hematology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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