The essential transcription factor for granulocyte differentiation, CCAAT/enhancer binding protein alpha (CEBPA), and its mutations or inhibition associated with acute myeloid leukemias
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F12%3A00010462" target="_blank" >RIV/00023736:_____/12:00010462 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The essential transcription factor for granulocyte differentiation, CCAAT/enhancer binding protein alpha (CEBPA), and its mutations or inhibition associated with acute myeloid leukemias
Original language description
CEBP? induces myeloid differentiation via up-regulation of specific genes involved in granulocyte maturation and in inhibition of myeloid cell proliferation. CEBPA is intronless and generates two isoforms as a result of the differential utilization of alternate translation start codon. CEBP? p30 inhibits DNA binding of CEBP? p42 and its transactivation fiction in the expression of key genes in granulocytic differentiation. CEBPA mutation a methylation of its promoter were detected in acute myeloid leukemia and have prognostic significance.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LC06044" target="_blank" >LC06044: Center for Experimental Hematology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Granulocytes: production, types and roles in disease
ISBN
978-1-61942-806-5
Number of pages of the result
36
Pages from-to
33-68
Number of pages of the book
142
Publisher name
Nova Science Publishers
Place of publication
New York
UT code for WoS chapter
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