The effect of helper epitopes and cellular localization of an antigen on the outcome of gene gun DNA immunization

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F14%3A00010902" target="_blank" >RIV/00023736:_____/14:00010902 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/gt.2013.81" target="_blank" >http://dx.doi.org/10.1038/gt.2013.81</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/gt.2013.81" target="_blank" >10.1038/gt.2013.81</a>

Result language
angličtina
Original language name
The effect of helper epitopes and cellular localization of an antigen on the outcome of gene gun DNA immunization
Original language description
The cellular localization of the antigen produced by DNA vaccines delivered by the gene gun was crucial for the effect of the p30 helper epitope on the E7-specific response, but the stronger immunity against the E7 antigen stimulated with the PADRE epitope was not noticeably dependent on this cellular localization. The higher potency of the PADRE epitope might be caused by its higher affinity to MHC class II molecules resulting in the observed stronger Th1 and weaker Th2 response in comparison with thep30 epitope
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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