Molecular diagnostics of myeloproliferative neoplasms (MPN)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F15%3A00011316" target="_blank" >RIV/00023736:_____/15:00011316 - isvavai.cz</a>
Result on the web
<a href="http://www.scopus.com/inward/record.url?eid=2-s2.0-84941259889&partnerID=40&md5=9f68a5a907336ff8dfc12bebb0aa2f8e" target="_blank" >http://www.scopus.com/inward/record.url?eid=2-s2.0-84941259889&partnerID=40&md5=9f68a5a907336ff8dfc12bebb0aa2f8e</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ejh.12578" target="_blank" >10.1111/ejh.12578</a>

Result language
angličtina
Original language name
Molecular diagnostics of myeloproliferative neoplasms (MPN)
Original language description
Since the discovery of the JAK2 V617F mutation in the majority of the myeloproliferative neoplasms (MPN) of polycythemia vera, essential thrombocythemia and primary myelofibrosis ten years ago, further MPN-specific mutational events, notably in JAK2 exon 12, MPL exon 10 and CALR exon 9 have been identified. These discoveries have been rapidly incorporated into evolving molecular diagnostic algorithms. The evolution of molecular diagnostic applications and platforms has occurred in parallel with the discovery of MPN-associated mutations and it therefore appears likely that emerging technologies such as next-generation sequencing and digital PCR will in the future, play an increasing role in the molecular diagnosis of MPN.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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