Circulating microRNAs: methodological aspects in detection of these biomarkers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F15%3A00011439" target="_blank" >RIV/00023736:_____/15:00011439 - isvavai.cz</a>

Result on the web

<a href="https://www.scopus.com/inward/record.url?eid=2-s2.0-84955600217&partnerID=40&md5=2e194913ee503d24be4632630de205e6" target="_blank" >https://www.scopus.com/inward/record.url?eid=2-s2.0-84955600217&partnerID=40&md5=2e194913ee503d24be4632630de205e6</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Circulating microRNAs: methodological aspects in detection of these biomarkers

Original language description

MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that regulate expression of protein-coding genes involved in important biological processes and (patho)physiological states. Circulating miRNAs are protected against degradation, indicating their relevant biological functions. Many studies have demonstrated an association of the specific profile of circulating miRNAs with a wide range of cancers as well as non-malignant diseases. These findings demonstrate the implication of circulating miRNAs in the pathogenesis of diseases and their potential as non-invasive disease biomarkers. However, methods for measurement of circulating miRNAs have critical technical hotspots, resulting in a discrepancy of the reported results and difficult definition of consensus disease biomarkers that may be implicated in clinical use. Here, we review functions of circulating miRNAs and their aberrant expression in particular diseases.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NT13847" target="_blank" >NT13847: Diagnostic and prognostic relevance of selected microRNAs in myelodysplastic syndromes</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia biologica

ISSN

0015-5500

e-ISSN

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Volume of the periodical

61

Issue of the periodical within the volume

6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

16

Pages from-to

203-218

UT code for WoS article

000000000000000

EID of the result in the Scopus database

2-s2.0-84955600217