The detection of human polyomaviruses MCPyV, HPyV6, and HPyV7 in malignant and non-malignant tonsillar tissues

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F16%3A00011377" target="_blank" >RIV/00023736:_____/16:00011377 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/jmv.24385" target="_blank" >http://dx.doi.org/10.1002/jmv.24385</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jmv.24385" target="_blank" >10.1002/jmv.24385</a>

Result language
angličtina
Original language name
The detection of human polyomaviruses MCPyV, HPyV6, and HPyV7 in malignant and non-malignant tonsillar tissues
Original language description
Merkel cell polyomavirus (MCPyV) is associated with Merkel cell carcinoma (MCC), a rare skin malignancy. Human polyomavirus 6 and 7 (HPyV6 and HPyV7) were identified on a skin but have not been associated with any pathology. The serology data suggests that infection with polyomaviruses occurs in childhood and they are widespread in population. However, the site of persistent infection has not been identified. The prevalence of MCPyV DNA in non-malignant tonsils increased with age (p < 0.05). While the prevalence of MCPyV DNA was significantly higher in the tumors than non-malignant tissues (35.7% vs. 10.2%) (p < 0.001), the prevalence of HPyV6 DNA (5.4% vs. 4.6%) and HPyV7 DNA (1.8% vs. 0.9%) were comparable. In all MCPyV DNA positive FF tissues early transcripts were detected. MCPyV, HPyV6 and HPyV7 DNAs were found in tonsils, suggesting that the tonsils may be a site of viral latency. The viral load was low indicating that only a fraction of cells are infected.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/NT13867" target="_blank" >NT13867: The relevance of newly discovered DNA viruses in healthy and immunocompromised subjects</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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