Low-dose actinomycin-D induces redistribution of wild-type and mutated nucleophosmin followed by cell death in leukemic cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F16%3A00011414" target="_blank" >RIV/00023736:_____/16:00011414 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/jcb.25420" target="_blank" >http://dx.doi.org/10.1002/jcb.25420</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jcb.25420" target="_blank" >10.1002/jcb.25420</a>

Result language

angličtina

Original language name

Low-dose actinomycin-D induces redistribution of wild-type and mutated nucleophosmin followed by cell death in leukemic cells

Original language description

We analyzed the distribution of both wild-type and mutated NPM (NPMmut) in human cell lines, before and after low-dose actD treatment, in living cells expressing exogenous fluorescently labeled proteins as well as using immunofluorescence staining of endogenous proteins in fixed cells. We conclude that although actD does not increase NPM concentration in the cytoplasm, it could improve the effect of standard chemotherapy in leukemias through more general mechanisms.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of cellular biochemistry

ISSN

0730-2312

e-ISSN

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Volume of the periodical

117

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

1319-1329

UT code for WoS article

000373741000005

EID of the result in the Scopus database

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