Development and evaluation of a secondary reference panel for BCR-ABL1 quantification on the International Scale

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F16%3A00011550" target="_blank" >RIV/00023736:_____/16:00011550 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/16:00092596 RIV/65269705:_____/16:00066093
Result on the web
<a href="http://dx.doi.org/10.1038/leu.2016.90" target="_blank" >http://dx.doi.org/10.1038/leu.2016.90</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/leu.2016.90" target="_blank" >10.1038/leu.2016.90</a>

Result language
angličtina
Original language name
Development and evaluation of a secondary reference panel for BCR-ABL1 quantification on the International Scale
Original language description
Molecular monitoring of chronic myeloid leukemia patients using robust BCR-ABL1 tests standardized to the International Scale (IS) is key to proper disease management, especially when treatment cessation is considered. Most laboratories currently use a time-consuming sample exchange process with reference laboratories for IS calibration. A World Health Organization (WHO) BCR-ABL1 reference panel was developed (MR 1 -MR 4), but access to the material is limited. In this study, we describe the development of the first cell-based secondary reference panel that is traceable to and faithfully replicates the WHO panel, with an additional MR 4.5 level. The secondary panel was calibrated to IS using digital PCR with ABL1, BCR and GUSB as reference genes and evaluated by 44 laboratories worldwide.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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