Expression of genes encoding centrosomal proteins and the humoral response against these proteins in chronic myeloid leukemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F17%3A00011650" target="_blank" >RIV/00023736:_____/17:00011650 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/17:10333043

Result on the web

<a href="http://dx.doi.org/10.3892/or.2016.5226" target="_blank" >http://dx.doi.org/10.3892/or.2016.5226</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/or.2016.5226" target="_blank" >10.3892/or.2016.5226</a>

Result language

angličtina

Original language name

Expression of genes encoding centrosomal proteins and the humoral response against these proteins in chronic myeloid leukemia

Original language description

In the present study, we showed that in comparison with healthy controls, the expression of four centrosomal genes (AURKA, HMMR, PLK1 and ESPL1) in the peripheral blood of CML patients was significantly enhanced at diagnosis and decreased to the basal level in most patients treated with imatinib mesylate for three months. In the remaining patients (17%), this decrease was delayed and was associated with worse overall survival. The detection of antibodies in sera showed that patients with higher overall antibody production had superior outcomes in terms of achieving major molecular response and failure-free survival. These data suggest that the dynamics of the response of centrosomal genes should be considered as a risk factor and immunity against centrosomal proteins may contribute to treatment response.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30205 - Hematology

Project

<a href="/en/project/NT13862" target="_blank" >NT13862: Utilization of centrosomal proteins for prognostication and vaccinotherapy of chronic myeloid leukemia</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncology reports

ISSN

1021-335X

e-ISSN

—

Volume of the periodical

37

Issue of the periodical within the volume

1

Country of publishing house

GR - GREECE

Number of pages

8

Pages from-to

547-554

UT code for WoS article

000390639800065

EID of the result in the Scopus database

2-s2.0-85006386932