Integrin expression and adhesivity to fibronectin in primary acute myeloid leukemia cells: impact of NPM1 and FLT3 mutations

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F20%3A00013040" target="_blank" >RIV/00023736:_____/20:00013040 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/" target="_blank" >https://doi.org/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ejh.13488" target="_blank" >10.1111/ejh.13488</a>

Result language
angličtina
Original language name
Integrin expression and adhesivity to fibronectin in primary acute myeloid leukemia cells: impact of NPM1 and FLT3 mutations
Original language description
Interaction of leukemia cells with the bone marrow extracellular matrix promotes cell survival and resistance to chemotherapy. In this work, we analyzed integrin expression and adhesivity to fibronectin in primary cells from patients with acute myeloid leukemia. The integrin αVβ3 is expressed in particular on CD34+ cells with NPM1 mutation and might have a prognostic value in patients with mutated NPM1. FLT3-ITD is associated with lower cell adhesivity, especially in patients with less differentiated leukemias.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology

Project
<a href="/en/project/GA16-16169S" target="_blank" >GA16-16169S: Analysis of the role of PAK family kinases in the regulation of hematopoietic cell interaction with extracellular matrix proteins</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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