Clonal heterogeneity in patients with cytogenetically normal acute myeloid leukemia with NPM1 mutations

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00067503" target="_blank" >RIV/00216224:14740/13:00067503 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/13:#0002209

Result on the web

<a href="http://informahealthcare.com/doi/abs/10.3109/10428194.2012.734618" target="_blank" >http://informahealthcare.com/doi/abs/10.3109/10428194.2012.734618</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/10428194.2012.734618" target="_blank" >10.3109/10428194.2012.734618</a>

Result language

angličtina

Original language name

Clonal heterogeneity in patients with cytogenetically normal acute myeloid leukemia with NPM1 mutations

Original language description

The nucleophosmin 1 (NPM1) gene is one of the most commonly mutated genes in acute myeloid leukemia (AML), occurring in approximately 60% of adult cytogenetically normal AML (CN-AML). To date, these mutations have only been detected in cells of the myeloid lineage, whereas the potential clonal involvement of the lymphoid lineage is controversial. In our study, NPM1 mutations were analyzed using the highly sensitive real-time quantitative polymerase chain reaction (RQ-PCR) method on fluorescence-activated cell-sorted (FACS) purified different circulating mature cell populations in patients with NPM1-mutated CN-AML. As expected, NPM1 mutations were found in myeloid blood cells, including CD14(+) monocytes and CD66b(+) granulocytes. However, we were alsoable to detect NPM1 mutations in CD19(+) B cells and CD3(-)14(-)16(+)56(+) natural killer (NK) cells, albeit at lower levels. Surprisingly, mutations were also detected in CD3(+) T cells from all analyzed patients.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Leukemia & Lymphoma

ISSN

1042-8194

e-ISSN

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Volume of the periodical

54

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

1056-1060

UT code for WoS article

000317661900026

EID of the result in the Scopus database

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