The clinical relevance of BAALC and ERG expression levels in pediatric AML

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F13%3A10209589" target="_blank" >RIV/00064203:_____/13:10209589 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/13:10209589

Result on the web

<a href="http://dx.doi.org/10.1038/leu.2012.233" target="_blank" >http://dx.doi.org/10.1038/leu.2012.233</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/leu.2012.233" target="_blank" >10.1038/leu.2012.233</a>

Result language

angličtina

Original language name

The clinical relevance of BAALC and ERG expression levels in pediatric AML

Original language description

Pediatric acute myeloid leukemia (AML) is a heterogeneous disease, for which survival rates have increased up to 70% over the past years. Approximately 45% of adult AML patients and 20% of pediatric AML patients are diagnosed with cytogenetically normalAML (CN-AML), which is currently classified and treated as a homogeneous intermediate-risk group. For future stratification of pediatric CN-AML, it is important to unravel the underlying molecular aberrations. For example, single-gene mutations such as NPM1 and CEBPA double mutations appeared to predict favorable outcome, whereas WT1 mutations and the cryptic NUP98/NSD1 translocation are of poor prognostic significance. In adult AML patients, the expression levels of specific genes have been associatedwith prognosis, mainly in CN-AML. For instance, high expression levels of BAALC (brain and acute leukemia cytoplasmic; 8q22) or ERG (E26 transformation-specific-related; 21q22) genes predict a poor prognosis in most adult AML studies, con

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Leukemia

ISSN

0887-6924

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

3

Pages from-to

735-737

UT code for WoS article

000316587300032

EID of the result in the Scopus database

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