In vivo validation of alternative FDXR transcripts in human blood in response to ionizing radiation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F20%3A00013136" target="_blank" >RIV/00023736:_____/20:00013136 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/20:10419282
Result on the web
<a href="https://doi.org/10.3390/ijms21217851" target="_blank" >https://doi.org/10.3390/ijms21217851</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms21217851" target="_blank" >10.3390/ijms21217851</a>

Result language
angličtina
Original language name
In vivo validation of alternative FDXR transcripts in human blood in response to ionizing radiation
Original language description
Following cell stress such as ionising radiation (IR) exposure, multiple cellular pathways are activated. We recently demonstrated that ferredoxin reductase (FDXR) has a remarkable IR-induced transcriptional responsiveness in blood. Here, we provided a first comprehensive FDXR variant profile following DNA damage. First, specific quantitative real-time polymerase chain reaction (qPCR) primers were designed to establish dose-responses for eight curated FDXR variants, all up-regulated after IR in a dose-dependent manner. The potential role of gender on the expression of these variants was tested, and neither the variants response to IR nor the background level of expression was profoundly affected, moreover, in vitro induction of inflammation temporarily counteracted IR response early after exposure.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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