Immunosuppression affects neutrophil functions: does calcineurin-NFAT signaling matter?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F21%3A00013299" target="_blank" >RIV/00023736:_____/21:00013299 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/21:00075060 RIV/00216224:14110/21:00120227
Result on the web
<a href="https://doi.org/10.3389/fimmu.2021.770515" target="_blank" >https://doi.org/10.3389/fimmu.2021.770515</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fimmu.2021.770515" target="_blank" >10.3389/fimmu.2021.770515</a>
Alternative languages
Result language
angličtina
Original language name
Immunosuppression affects neutrophil functions: does calcineurin-NFAT signaling matter?
Original language description
Neutrophils are innate immune cells with important roles in antimicrobial defense. However, impaired or dysregulated neutrophil function can result in host tissue damage, loss of homeostasis, hyperinflammation or pathological immunosuppression. A central link between neutrophil activation and immune outcomes is emerging to be the calcineurin-nuclear factor of activated T cells (NFAT) signaling pathway, which is activated by neutrophil detection of a microbial threat via pattern recognition receptors and results in inflammatory cytokine production. This potent pro-inflammatory pathway is also the target of several immunosuppressive drugs used for the treatment of autoimmune disorders, during solid organ and hematopoietic cell transplantations, and as a part of anti-cancer therapy: but what effects these drugs have on neutrophil function, and their broader consequences for immune homeostasis and microbial defense are not yet known.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in immunology
ISSN
1664-3224
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
[November]
Country of publishing house
CH - SWITZERLAND
Number of pages
9
Pages from-to
"art. no. 770515"
UT code for WoS article
000719673100001
EID of the result in the Scopus database
2-s2.0-85119254134