Prophylactic vaccines against cancers of non-infectious origin: a dream or a real possibility?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F21%3A00013358" target="_blank" >RIV/00023736:_____/21:00013358 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/21:00552726 RIV/00216208:11310/21:10443068
Result on the web
<a href="https://doi.org/10.21101/cejph.a7219" target="_blank" >https://doi.org/10.21101/cejph.a7219</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21101/cejph.a7219" target="_blank" >10.21101/cejph.a7219</a>

Result language
angličtina
Original language name
Prophylactic vaccines against cancers of non-infectious origin: a dream or a real possibility?
Original language description
The dramatic progress in tumour biology and immunology in the past several years has opened new avenues for the treatment and prevention of cancer. One of the great contributions of the immunotherapeutic approaches is an increasing understanding of the immunology of cancer, which is, gradually creating conditions for the development of prophylactic anti-cancer vaccines. Efficient vaccines have been developed and employed for the prophylaxis of two frequent cancers of viral origin, namely cervical cancer and liver cancer. The new knowledge on the interactions between the immune system and the malignant tumors seems to provide means for the development of prophylactic vaccines against cancers developing due to the mutations in the proto-oncogenes converting their products into oncoproteins. According to the present estimates, these cancers form a great majority of human malignancies. Recent evidence has indicated that the immune system recognizes such mutated proteins, and that the development of cancer is due to the failure of the immune system to eliminate neoplastic cells. Followingly, it can be expected that inducing immunity against the mutated epitopes will increase the capacity of the body to deal with the initiated precancerous cells.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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