TGF-β induces matrisome pathological alterations and EMT in patient-derived prostate cancer tumoroids

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F24%3A00013592" target="_blank" >RIV/00023736:_____/24:00013592 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/24:00081512 RIV/00216224:14110/24:00135447
Result on the web
<a href="https://doi.org/10.1016/j.matbio.2023.11.001" target="_blank" >https://doi.org/10.1016/j.matbio.2023.11.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.matbio.2023.11.001" target="_blank" >10.1016/j.matbio.2023.11.001</a>

Result language
angličtina
Original language name
TGF-β induces matrisome pathological alterations and EMT in patient-derived prostate cancer tumoroids
Original language description
Extracellular matrix (ECM) tumorigenic alterations resulting in high matrix deposition and stiffening are hallmarks of adenocarcinomas and are collectively defined as desmoplasia. Here, we thoroughly analysed primary prostate cancer tissues obtained from numerous patients undergoing radical prostatectomy to highlight reproducible structural changes in the ECM leading to the loss of the glandular architecture. Starting from patient cells, we established prostate cancer tumoroids (PCTs) and demonstrated they require TGF-β signalling pathway activity to preserve phenotypical and structural similarities with the tissue of origin. By modulating TGF-β signalling pathway in PCTs, we unveiled its role in ECM accumulation and remodelling in prostate cancer. We also found that TGF-β-induced ECM remodelling is responsible for the initiation of prostate cell epithelial-to-mesenchymal transition (EMT) and the acquisition of a migratory, invasive phenotype. Our findings highlight the cooperative role of TGF-β signalling and ECM desmoplasia in prompting prostate cell EMT and promoting tumour progression and dissemination.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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