The SNP rs460089 in the gene promoter of the drug transporter OCTN1 has prognostic value for treatment-free remission in chronic myeloid leukemia patients treated with imatinib
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F24%3A00013593" target="_blank" >RIV/00023736:_____/24:00013593 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00135463 RIV/00216208:11110/24:10473621 RIV/61989592:15110/24:73621768 RIV/65269705:_____/24:00078548 and 2 more
Result on the web
<a href="https://doi.org/10.1038/s41375-023-02109-2" target="_blank" >https://doi.org/10.1038/s41375-023-02109-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41375-023-02109-2" target="_blank" >10.1038/s41375-023-02109-2</a>
Alternative languages
Result language
angličtina
Original language name
The SNP rs460089 in the gene promoter of the drug transporter OCTN1 has prognostic value for treatment-free remission in chronic myeloid leukemia patients treated with imatinib
Original language description
Membrane transporters are important determinants of drug bioavailability. Their expression and activity affect the intracellular drug concentration in leukemic cells impacting response to therapy. Pharmacogenomics represents genetic markers that reflect allele arrangement of genes encoding drug transporters associated with treatment response. In previous work, we identified SNP rs460089 located in the promotor of SLC22A4 gene encoding imatinib transporter OCTN1 as influential on response of patients with chronic myeloid leukemia treated with imatinib.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Leukemia
ISSN
0887-6924
e-ISSN
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Volume of the periodical
38
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
318-325
UT code for WoS article
001129500800001
EID of the result in the Scopus database
2-s2.0-85180252677