Attenuated cell cycle and DNA damage response transcriptome signatures and overrepresented cell adhesion processes imply accelerated progression in patients with lower‐risk myelodysplastic neoplasms
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F24%3A00013596" target="_blank" >RIV/00023736:_____/24:00013596 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/24:10473670 RIV/00216208:11310/24:10473670 RIV/61989592:15110/24:73626530 RIV/00064165:_____/24:10473670
Result on the web
<a href="https://doi.org/10.1002/ijc.34834" target="_blank" >https://doi.org/10.1002/ijc.34834</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ijc.34834" target="_blank" >10.1002/ijc.34834</a>
Alternative languages
Result language
angličtina
Original language name
Attenuated cell cycle and DNA damage response transcriptome signatures and overrepresented cell adhesion processes imply accelerated progression in patients with lower‐risk myelodysplastic neoplasms
Original language description
Patients with myelodysplastic neoplasms (MDS) are classified according to the risk of acute myeloid leukemia transformation. Some lower-risk MDS patients (LR-MDS) progress rapidly despite expected good prognosis. Using diagnostic samples, we aimed to uncover the mechanisms of this accelerated progression at the transcriptome level. DNA damage response (DDR) and energy metabolism-related pathways were downregulated in prMDS samples, whereas cell adhesion processes were upregulated. Also, prMDS samples showed high levels of aberrant splicing and global lncRNA expression that may contribute to the attenuation of DDR pathways. The attenuation of DDR-related gene-expression signature may refine risk assessment in LR-MDS patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International journal of cancer
ISSN
0020-7136
e-ISSN
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Volume of the periodical
154
Issue of the periodical within the volume
9
Country of publishing house
CH - SWITZERLAND
Number of pages
17
Pages from-to
1652-1668
UT code for WoS article
001136704500001
EID of the result in the Scopus database
2-s2.0-85181529959