Mass-spectrometric identification of proteins and pathways responsible for fouling on poly(ethylene glycol) methacrylate polymer brushes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F24%3A00013642" target="_blank" >RIV/00023736:_____/24:00013642 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/24:00586901 RIV/60076658:12310/24:43908824
Result on the web
<a href="https://doi.org/10.1002/mabi.202300558" target="_blank" >https://doi.org/10.1002/mabi.202300558</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mabi.202300558" target="_blank" >10.1002/mabi.202300558</a>

Result language
angličtina
Original language name
Mass-spectrometric identification of proteins and pathways responsible for fouling on poly(ethylene glycol) methacrylate polymer brushes
Original language description
Prevention of fouling from proteins in blood plasma attracts significant efforts, and great progress is made in identifying surface coatings that display antifouling properties. In particular, poly(ethylene glycol) (PEG) is widely used and dense PEG-like cylindrical brushes of poly[oligo(ethylene glycol) methacrylate] (poly(OEGMA)) can drastically reduce blood plasma fouling. Herein, a comprehensive study of the variation of blood plasma fouling on this surface, including the analysis of the composition of protein deposits on poly(OEGMA) coatings after contact with blood plasma from many different donors, is reported. Correlation between the plasma fouling behavior and protein deposit composition points to the activation of the complement system as the main culprit of dramatically increased and accelerated deposition of blood plasma proteins on this type of antifouling coating, specifically through the classical pathway. These findings are consistent with observations on PEGylated drug carriers and highlight the importance of understanding the potential interactions between antifouling coatings and their environment.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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