Good manufacturing practice-grade generation of CD19 and CD123-specific CAR-T cells using piggyBac transposon and allogeneic feeder cells in patients diagnosed with B-cell non-Hodgkin lymphoma and acute myeloid leukemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F24%3A00013709" target="_blank" >RIV/00023736:_____/24:00013709 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/24:10497605
Result on the web
<a href="https://doi.org/10.3389/fimmu.2024.1415328" target="_blank" >https://doi.org/10.3389/fimmu.2024.1415328</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fimmu.2024.1415328" target="_blank" >10.3389/fimmu.2024.1415328</a>
Alternative languages
Result language
angličtina
Original language name
Good manufacturing practice-grade generation of CD19 and CD123-specific CAR-T cells using piggyBac transposon and allogeneic feeder cells in patients diagnosed with B-cell non-Hodgkin lymphoma and acute myeloid leukemia
Original language description
The non-viral production of CAR-T cells through electroporation of transposon DNA plasmids is an alternative approach to lentiviral/retroviral methods. This method is particularly suitable for early-phase clinical trials involving novel types of CAR-T cells. The primary disadvantage of non-viral methods is the lower production efficiency compared to viral-based methods, which becomes a limiting factor for CAR-T production, especially in chemotherapy-pretreated lymphopenic patients.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/NU22-05-00374" target="_blank" >NU22-05-00374: Gene engineered killer T cells for the therapy of acute myeloid leukemia.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in immunology
ISSN
1664-3224
e-ISSN
—
Volume of the periodical
15
Issue of the periodical within the volume
August
Country of publishing house
CH - SWITZERLAND
Number of pages
11
Pages from-to
"art. no. 1415328"
UT code for WoS article
001299139200001
EID of the result in the Scopus database
2-s2.0-85202049539