Molecular taxonomy of myelodysplastic syndromes and its clinical implications

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F24%3A00013727" target="_blank" >RIV/00023736:_____/24:00013727 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1182/blood.2023023727" target="_blank" >https://doi.org/10.1182/blood.2023023727</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1182/blood.2023023727" target="_blank" >10.1182/blood.2023023727</a>

Result language
angličtina
Original language name
Molecular taxonomy of myelodysplastic syndromes and its clinical implications
Original language description
Myelodysplastic syndromes (MDS) are clonal hematologic disorders characterized by morphologic abnormalities of myeloid cells and peripheral cytopenias. Although genetic abnormalities underlie the pathogenesis of these disorders and their heterogeneity, current classifications of MDS rely predominantly on morphology. We performed genomic profiling of 3233 patients with MDS or related disorders to delineate molecular subtypes and define their clinical implications. The prognostic influence of BM blasts depended on the genetic subtypes. Within genetic subgroups, therapy-related MDS and myelodysplastic/myeloproliferative neoplasms had comparable clinical and outcome profiles to primary MDS. In conclusion, genetically-derived subgroups of MDS are clinically relevant and might inform future classification schemas and translational therapeutic research.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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