Myelodysplastic syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F24%3A00013753" target="_blank" >RIV/00023736:_____/24:00013753 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/B978-0-443-15717-2.00046-9" target="_blank" >https://doi.org/10.1016/B978-0-443-15717-2.00046-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-443-15717-2.00046-9" target="_blank" >10.1016/B978-0-443-15717-2.00046-9</a>
Alternative languages
Result language
angličtina
Original language name
Myelodysplastic syndrome
Original language description
Myelodysplastic neoplasm (MDS) constitute a group of age-associated heterogeneous clonal hematopoietic disorders characterized by the combination of persistent unexplained cytopenias and morphologic dysplasia in one or more of the major hematopoietic cell lines, ineffective hematopoiesis, and an increased risk of progression to acute myeloid leukemia (AML). A conventional karyotype is present in about 50% of cases. Cytogenetic abnormalities based on losses of chromosomal material are most frequent than gains such as trisomy 8 or trisomy 21. Next-generation sequencing found somatic mutations in approximately 90% of patients with MDS. One or more driver mutations are associated with the pathogenesis of MDS in most patients with MDS. The detection of a driver mutation helps in cases when morphology is not diagnostic. Genomics has impact on the classification of MDS. The recently developed fifth edition of the WHO classification of diseases (WHO, 2022) and International Consensus (IC) classification of hematologic neoplasms included MDS with mutated SF3B1 and MDS with mutated TP53 (multi-hit TP53 mutation or TP53 mutation and complex karyotype) entities important for risk stratification. Epigenetic mechanisms, immune dysregulation, and proinflammatory signaling play essential roles in the pathogenesis of MDS. The development of targeted and immune therapies is based on molecular and genetic characterization of MDS, and understanding the pathogenic mechanisms of MDS.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Comprehensive hematology and stem cell research: volume 1-5
ISBN
978-044315718-9
Number of pages of the result
26
Pages from-to
"V2:144"-"V2:169"
Number of pages of the book
2572
Publisher name
Elsevier
Place of publication
Amsterdam
UT code for WoS chapter
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