TP53 mutation variant allele frequency is a potential predictor for clinical outcome of patients with lower-risk myelodysplastic syndromes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F16%3A00011557" target="_blank" >RIV/00023736:_____/16:00011557 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/16:10324351 RIV/00064165:_____/16:10324351
Result on the web
<a href="http://dx.doi.org/10.18632/oncotarget.9200" target="_blank" >http://dx.doi.org/10.18632/oncotarget.9200</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.18632/oncotarget.9200" target="_blank" >10.18632/oncotarget.9200</a>
Alternative languages
Result language
angličtina
Original language name
TP53 mutation variant allele frequency is a potential predictor for clinical outcome of patients with lower-risk myelodysplastic syndromes
Original language description
TP53 mutations are frequently detected in patients with higher-risk myelodysplastic syndromes (MDS); however, the clinical impact of these mutations on the disease course of patients with lower-risk MDS is unclear. In this study of 154 lower-risk MDS patients, TP53 mutations were identified in 13% of patients, with prevalence in patients with del(5q) (23.6%) compared to non-del(5q) (3.8%). Two-thirds of the mutations were detected at the time of diagnosis, and one-third were detected during the course of the disease.Our results indicate that the clinical impact of TP53 mutations in lower-risk MDS patients depends on the level of mutational burden.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oncotarget
ISSN
1949-2553
e-ISSN
—
Volume of the periodical
7
Issue of the periodical within the volume
24
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
36266-36279
UT code for WoS article
000377756800061
EID of the result in the Scopus database
—