Lenalidomide treatment in lower risk myelodysplastic syndromes-The experience of a Czech hematology center. (Positive effect of erythropoietin +/- prednisone addition to lenalidomide in refractory or relapsed patients)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F18%3A00506807" target="_blank" >RIV/68378050:_____/18:00506807 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/18:10377019 RIV/00064165:_____/18:10377019 RIV/00023736:_____/18:00011971

Result on the web

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0145212618300778?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0145212618300778?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.leukres.2018.03.015" target="_blank" >10.1016/j.leukres.2018.03.015</a>

Result language

angličtina

Original language name

Lenalidomide treatment in lower risk myelodysplastic syndromes-The experience of a Czech hematology center. (Positive effect of erythropoietin +/- prednisone addition to lenalidomide in refractory or relapsed patients)

Original language description

Lenalidomide therapy represents meaningful progress in the treatment of anemic patients with myelodysplastic syndromes with del(5q). We present our initial lenalidomide experience and the positive effect of combining erythropoietin and steroids with lenalidomide in refractory and relapsed patients. We treated by lenalidomide 55 (42 female, 13 male, median age 69) chronically transfused lower risk MDS patients with del(5q) (45) and non-del( 5q) (10). Response, meaning transfusion independence (TI) lasting >= eight weeks, was achieved in 38 (90%) of analyzed patients with del(5q), of whom three achieved TI only by adding erythropoietin +/- prednisone. Another five patients responded well to this combination when their anemia relapsed later during the treatment. In the non-del(5q) group only one patient with RARS-T reached TI. Cytogenetic response was reached in 64% (32% complete, 32% partial response). The TP53 mutation was detected in 7 (18%) patients, four patients progressed to higher grade MDS or acute myeloid leukemia (AML). All seven RAEB-1 patients cleared bone marrow blasts during lenalidomide treatment and reached complete remission (CR), however, three later progressed to higher grade MDS or AML. Lenalidomide represents effective treatment for del(5q) group and combination with prednisone and erythropoietin may be used for non-responders or therapy failures.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10601 - Cell biology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Leukemia Research

ISSN

0145-2126

e-ISSN

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Volume of the periodical

69

Issue of the periodical within the volume

June

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

12-17

UT code for WoS article

000436483100003

EID of the result in the Scopus database

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