Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F01%3A00000162" target="_blank" >RIV/00023752:_____/01:00000162 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate

Original language description

N-Acetyl-aspartyl-glutamate (NAAG), the most abundant neuroactive peptide in the mammalian CNS, has only two known specific targets in brain tissue: ionotropic glutamate receptor of N-methyl-D-aspartate type and metabotropic G-protein linked glutamate receptors of class II. Several observations have pointed to a nexus between changes in the level of NAAG in brain and the development of neurodegenerative and mental diseases. The precise role of NAAG in neurodegeneration (or in healthy brain tissue) is, however, less clear. There could be a fine balance between the neuroprotective and neurotoxic actions of NAAG, depending on which one of the two populations of receptors targeted by NAAG is more active. The decisive factor could be the extracellular concentration (rather than overall tissue level) of NAAG and this can be manipulated in an animal model in vivo. Therefore, we have been using quantitative morphology, electron microscopy and molecular biological techniques to study and charac

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/LN00B122" target="_blank" >LN00B122: Neuropsychiatric Research Center</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Psychiatrie

ISSN

1211-7579

e-ISSN

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Volume of the periodical

5

Issue of the periodical within the volume

Suppl. 2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

3

Pages from-to

102-104

UT code for WoS article

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EID of the result in the Scopus database

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