N-acetyl-L-aspartyl-L-glutamate changes functional and structural properties of rat blood-brain barrier.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F02%3A20020028" target="_blank" >RIV/67985823:_____/02:20020028 - isvavai.cz</a>

Alternative codes found

RIV/00023752:_____/02:00000207

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

N-acetyl-L-aspartyl-L-glutamate changes functional and structural properties of rat blood-brain barrier.

Original language description

Intracerebroventricular administration of N-acetyl-L-aspartyl-L-glutamate (NAAG), an agonist at group II metabotropic and NR1/NR2D-containing NMDA ionotropic glutamate receptors, increased permeability of the blood-brain barrier (BBB) to serum albumin inthe striatum but produced no similar effects in the entorhinal cortex and in the hippocampal formation. Electron microscopy showed that NAAG, but not its hydrolytic products L-glutamate and N-acetyl-L-aspartate, increased the number of transport vesicles in the hippocampal endothelial cells. Furthermore, immunocytochemistry detected NR2D subunits on hippocampal capillaries. Consequently, NAAG may have influenced the vesicular transport via NMDA receptors. There was, however, no correlation with the regional pattern of BBB changes (increased permeability in the striatum) that, in turn, could not be directly related to the NAAG-induced neurodegeneration described previously in the hippocampus where no significant changes in BBB permeabil

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

OECD FORD branch

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Project

<a href="/en/project/GA309%2F99%2F0211" target="_blank" >GA309/99/0211: Localization, distribution and function of glutamate receptor in brain capillary barrier</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroscience Letters

ISSN

0304-3940

e-ISSN

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Volume of the periodical

317

Issue of the periodical within the volume

2

Country of publishing house

IE - IRELAND

Number of pages

4

Pages from-to

85-88

UT code for WoS article

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EID of the result in the Scopus database

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