Role of glutamate receptor in the brain capillary barrier

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F01%3A00000199" target="_blank" >RIV/00023752:_____/01:00000199 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Role of glutamate receptor in the brain capillary barrier
Original language description
Intracerebroventricular administration of N-acetyl-L-aspartyl-L-glutamate (NAAG) and quinolinic acid (QUIN) significantly increased the permeability of blood brain barrier (BBB) to serum albumin. While NAAG was only effective in the striatum, QUIN also increased the entry of serum albumin into the hippocampus, in addition to the striatum. NMDA receptor antagonist, MK-801 blocked the action of QUIN but not that of NAAG. Neither L-glutamate (L-GLU) nor N-acetyl-L-aspartate (NAA), potential products of thehydrolysis of NAAG, had any effect on the passage of albumin across the BBB. Thus NAAG can change the permeability of the BBB but the changes coincide neither in location nor in pharmacology with the NAAG-induced neurodegeneration in the hippocampus.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/GA309%2F99%2F0211" target="_blank" >GA309/99/0211: Localization, distribution and function of glutamate receptor in brain capillary barrier</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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