Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F03%3A00000282" target="_blank" >RIV/00023752:_____/03:00000282 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801

Original language description

Haloperidol is a potent D2 antagonist, belonging to the so-called group of typical antipsychotics. It is effectively used in the treatment of schizophrenia. In our experimental setting we have evaluated the effects of haloperidol on psychosis-like reaction induced by non-competitive NMDA glutamate receptor antagonist, MK-801. We have monitored the locomotor reaction of rats in the open field, whereas we have targeted to evaluate the effects of haloperidol on hyperlocomotion induced by MK-801. We have found that MK-801 induced hyperolocomotor reaction was efficiently diminished by administration of haloperidol in a dose dependent manner. In our experimental setting we conclude that haloperidol was effective in counteracting MK-801 induced hyperlocomotion. Inasmuch as this model serves as a model of psychosis, we can extrapolate that haloperidol has an antipsychotic effect.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Psychiatrie

ISSN

1211-7579

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

Suppl. 3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

50-54

UT code for WoS article

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EID of the result in the Scopus database

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